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Information × Registration Number 0223U005643, 0121U111529 , R & D reports Title Multicomponent contamination with aerosol particulate matter, persistent toxic pollutants, heavy metals: development of risk assessment methodology, sensing, neuroprotection to identify essential variables in the services of assessment of related SDG indicators. popup.stage_title Head Borysova Tatiana О., д.б.н. Registration Date 26-12-2023 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 An algorithm for determining the joint neurotoxic effect of pollutants has been developed. It has been shown that copper and mercury, which are among the main environmental pollutants, caused a decrease in the accumulation of the excitatory neurotransmitter [3H]aspartate and an increase in its unstimulated release from the rat brain nerve terminals. Aerosol particulate matter, created during military operations, namely from the combustion of a biomass mixture, also caused a decrease in the accumulation of the neurotransmitter [3H]aspartate and an increase in its unstimulated release from rat brain nerve terminals. The combined effect of mercury or copper and solid aerosol particles did not lead to a more significant decrease in the accumulation of the neurotransmitter [3H]aspartate, as well as an increase in the unstimulated release of [3H]aspartate from the rat brain nerve terminals compared to the effect of a single pollutant. Screening of modern nanoparticles was carried out in order to prevent the development of the above-mentioned neurotoxic effect. It has been shown that fullerene C60 alone can cause a disturbance of the excitatory-inhibitory balance in nerve terminals, which was shown by increasing the extracellular level of the excitatory neurotransmitter [3H]aspartate and the inhibitory neurotransmitter [3H]GABA in the nerve terminals, and therefore fullerenes can not be used to prevent the development of neurotoxicity under the influence of copper. The complex combined effect of pollutants - solid aerosol particles created during military operations, and mercury and copper - was shown, which is very important for creating prognostic models for determining risks to human health under normal conditions and in the case of natural and man-made disasters and for determining significant variables in the assessment services of relevant SDG indicators (sustainable development goals).   Product Description popup.authors Borisov Arseniy A Dudarenko Marina Volodymyrivna Krisanova Natalia Valeriivna Paliienko Konstantin Olegovych Pastukhov Artem Olegovych Pozdnyakova Natalia Heorgiivna Tarasenko Alla S popup.nrat_date 2023-12-26 Close