Search academic texts

Information × Registration Number 0223U005816, 0121U107435 , R & D reports Title Synthesis and study of fused heterocyclic systems containing the 7-deazapurine fragment popup.stage_title Head Oleh B. Smolii, д.х.н. Registration Date 31-12-2023 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 Approaches to the synthesis of new fused derivatives of pyrrolo[2,3-d]pyrimidine (7-deazapurine) have been developed. A series of functionally substituted pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidines was synthesized on the basis of previously undescribed methyl 7-(2-bromoethyl)-4-chloropyrrolo[2,3-d]pyrimidine-6-carboxylate. A quick and affordable method of obtaining new tricyclic derivatives of 7-deazapurine – structural analogues of trilaciclib – a CDK 4/6 kinase inhibitor, promising in protecting the bone marrow from the harmful effects of chemotherapy in small cell lung cancer, has been found. Product Description popup.authors Biletskii Igor І. Verves Evgeniy V. Kucher Oleksandr V. Muzychka Liubov V. Yaremchuk Iryna О. popup.nrat_date 2023-12-31 Close