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Information × Registration Number 0224U000122, 0122U002461 , R & D reports Title Cytokinins of medicinal basidial mushrooms: oncostatic and immunomodulatory effects in tumor cell cultures popup.stage_title Head Kosakivska Iryna V., д.б.н. Registration Date 02-01-2024 Organization Department for special training National academy of science of Ukraine at Kiev University popup.description2  The species specificity of cytokinin production by the mycelial biomass of medicinal mushrooms Flammulina velutipes, Cyclocybe aegerita, and Hericium erinaceus in vitro was established. The greatest cytotoxic effect on the growth and development of HeLa human cervical cancer cells was revealed by the purified cytokinin fractions from the H. erinaceus, the mycelial biomass of which was characterized by the highest total content of cytokinins. Preparations from the mushroom C. aegerita demonstrated a cytostatic effect. Cytokinin fractions isolated from the mycelia of F. velutipes, C. aegerita and H. erinaceus increased the expression level of pro-inflammatory cytokines (TGF-beta and TNF-alfa) of lymphocytic cells MT-4, ans well as almost halved the percentage of dead cells of mouse aortic endothelium MAES under conditions of lead sulfate damage. These results support the assumption that the biologically active substances of medicinal mushrooms with high pharmacological potential include cytokinins. Product Description popup.authors Al-Maali Galeb A. Atamanchuk Alisa R. Bisko Nina Anatoliivna Vedenychova N. P. Harmanchuk Liudmyla V. Kot Larysa I. Lyashenko Volodymyr A. Omechenko Irina V. popup.nrat_date 2024-01-02 Close