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Information × Registration Number 0224U000248, 0122U001430 , R & D reports Title Study of regularities of development of endocrine disorders and concomitant diseases associated with normocalcemic disorders of parathyroid glands in persons affected by the Chornobyl NPP accident popup.stage_title Head Kaminskyi Oleksii V., Доктор медичних наук Registration Date 04-01-2024 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  In adult and childhood survivors of the Chornobyl NPP accident and service members of the Armed Forces of Ukraine, a reliable influence of secondary non-renal normocalcemic hyperparathyroidism on the development of a number of comorbid conditions, namely arterial hypertension, arrhythmia, dyslipidemia, disorders of carbohydrate metabolism, autoimmune thyroiditis and nodular goiter, was revealed. Among the Chornobyl NPP accident survivors the parathyroid abnormalities were diagnosed in 24.1% of cases, which is 1.5 times more than in the control group, in which this indicator was 16.5% (р ≤ 0.005). The gender and age trend of the annual increase in the frequency of detection of normocalcemic non-renal hyperparathyroidism was revealed in all study groups (1.5-fold per 5 years) and in controls (1.3-fold per 5 years). Pathogenetic relationships between secondary normocalcemic hyperparathyroidism and other non-malignant endocrine disorders in adults and children have been revealed. People over the age of 50 and women were the most sensitive. The highest frequency of normocalcemic non-renal hyperparathyroidism was found in irradiated individuals with type 2 diabetes and obesity (33.5% and 33.3%, respectively) vs. the control group (22.9 % and 15.8 %, respectively). A significant increase in the frequency of parathyroid hyperplasia and adenoma was found in descendants of the Chornobyl NPP accident survivors both under the prospective examination (49 %, p ≤ 0.05) and retrospective data review (48.1 %, p ≤ 0.05) vs. the comparison group against a background of persistent euparathyroidism. Clinical approaches were developed for the correction and treatment of secondary normocalcemic hyperparathyroidism, including in service members of the Armed Forces of Ukraine. Product Description popup.authors Afanasyev Dmytro E. Kopylova Olga V. Muraviova Iryna M. Chykalova Iryna Grygorivna popup.nrat_date 2024-01-04 Close