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0224U000330,
0123U100161
,
Improving chemoradiation therapy for squamous cell carcinoma of the head and neck in extreme conditions.
Mitriaieva Nataliia А., Доктор біологічних наук
Starenkyi Viktor P., Доктор медичних наук
05-01-2024
State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine"
The object of research: is the Squamous cell carcinoma of the head and neck. The aim of the study: is to develop a technology for a shortened course of chemoradiotherapy for head and neck cancer in extreme conditions, taking into account the mechanisms of tumor radioresistance. Research methods and equipment: radiological, morphological, clinical-instrumental, enzyme-linked immunosorbent assay (ELISA), statistical methods, "Clinac-600C" linear accelerator, Eclipse 8.9 planning system, "Immunochem-2100" enzyme immunoassay analyzer. Theoretical and practical results: the peculiarities of distant radiotherapy with cisplatin in patients with head and neck cancer have been evaluated, considering limiting factors, and the application of accelerated treatment regimens in extreme conditions has been substantiated. A method of radiation therapy has been developed, in which the daily dose is increased from 2 to 2.4 Gy, allowing the duration of treatment to be reduced by 1.5–2 weeks. Clinical efficacy with an accelerated course is higher than with a classical scheme due to a larger proportion of complete response (73.3% against 53.3%). Early radiation toxicity with accelerated courses of distant radiation therapy is 20% higher than with classical fractionation due to II–III grade mucositis. Novelty: for the first time, a method of accelerated radiation therapy in patients with head and neck cancer has been proposed, which allows reducing the duration of treatment from 7 to 5-5.5 weeks while maintaining effectiveness and a slight increase in II-III grade radiation toxicity by 20%. Effective implementation: reduction in the duration and costs of inpatient treatment, averaging 7200 UAH per patient per treatment course. Field of application: oncology, radiation therapy.
Artiukh Serhii Volodymyrovych
Bilozor Nataliia Volodymyrivna
Bilchenko Iryna Viktorivna
Vasyliev Leonid Leonidovych
Grebinyk Lidiya Volodymyrivna
Danylyuk Svitlana Volodymyrivna
Kolomatska Viktoriia Volodymyrivna
Kondrashova Olena Ivanivna
Nasonova Alla Mykolaivna
Nemaltsova Kateryna Volodymyrivna
Pasmor Anastasiia Andriivna
Pushkar Olena Serhiivna
Pshyshevska Liudmyla Anatoliivna
Roman Nataliia Ivanivna
Samofalov Ihor Oleksandrovych
Svynarenko Andrii Viktorovych
Slobodianiuk Olha Volodymyrivna
Sukhina Olena Mykolayivna
Tykholіz Ihor Stepanovych
2024-01-05
Updated: 2026-01-08
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