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Information × Registration Number 0224U000362, 0119U002508 , R & D reports Title The study of the biochemical mechanisms of smooth muscle cells functioning as Са2+-dependent tenzoelectrochemical receptor system. popup.stage_title Head Kosterin Serhii O., Доктор біологічних наук Registration Date 05-01-2024 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 The report (final) contains the results of research that were obtained during: - further comparative study of the properties (kinetic, catalytic, energetic) of Mg2+,ATP-dependent Ca2+- and Na+(K+) and H+ transport systems of the plasma membrane, mitochondria and sarcoplasmic reticulum of smooth muscles; - elucidation of the role of ATP-dependent Ca, Na and H ion transport systems in controlling of the intracellular concentration of physiologically significant cations in smooth muscle cells using calixarenes as specific effectors of these systems; - conducting research on the influence of calmodulin antagonists on Ca2+ accumulation in myometrial mitochondria and their membrane potential. With the application of the Petri net methodology to characterize the functional state of mitochondria (parameters - polarization of the mitochondrial membrane, transport of Ca, Na and H ions, effective hydrodynamic diameter), it was planned to clarify the laws of action of nitroactive compounds (nitroprusside and sodium nitrite) on the properties of the specified subcellular structures; - studying the influence of heavy metal ions on the structural and functional properties of the contractile complex of the myometrium (actomyosin, myosin, myosin subfragment I); - improvements to the previously approved mathematical model of Ca2+-dependent control of contractile activity of smooth muscle cells.   Product Description popup.authors Babich Lidiya Grygorivna Bevza Olexandre Vasylyovychy Tetiana Veklich Danylovych Hanna Victorivna Danylovuch Yuriy Volodymyrosych Kibiriev Volodymyr K. Karakhim Sergii O Olha V. Tsymbaliuk Chunikhin Oleksandr Yu. Shkrabak Oleksandr A. Shlykov Serhiy Georgiyovich popup.nrat_date 2024-01-05 Close