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Information × Registration Number 0224U000419, 0120U104883 , R & D reports Title Enzymes of post-translational modifications of microtubule proteins as targets for inhibition of the excitability of primary nociceptive neurons popup.stage_title Head Karpov Pavlo A., Доктор біологічних наук Registration Date 07-01-2024 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2  As a result of the project, the mechanisms of pain signal initiation on primary afferent sensory neurons were described and demonstrated, and a number of compounds with predicted activity against two groups of proteins involved in this process were proposed. One of the key results of the project is the creation of a minilibrary of modulators that were studied in silico. Lead compounds with predicted activity against both groups, with different levels of selectivity, were consistently tested experimentally on animal models of pain, and the destructive consequences of inhibition of the studied enzymes were recorded by confocal microscopy and visualization of the state of the cytoskeleton. Product Description popup.authors Karpov Pavel A. Novozhylov Dmytro O. Rabokon Anastasiia M. Samofalova Dariya O. Stikhilyas Mariya M. popup.nrat_date 2024-01-07 Close