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Information × Registration Number 0224U000474, 0123U100785 , R & D reports Title Study of the impact of COVID-19 on the pathogenesis and course of chronic B-cell lymphocytic leukemia in victims of the accident at the Chernobyl nuclear power plant popup.stage_title Head Diahil Irina , Доктор медичних наукChumak Anatolii , Доктор медичних наук Registration Date 08-01-2024 Organization State institution "National Scientific Center of Radiation Medicine of the National Academy of Medical Sciences of Ukraine" popup.description2  IONIZING RADIATION, B CELL RECEPTOR STEREOTYPY, CHRONIC LYMPHOCYTIC LEUKEMIA, SARS-COV-2. The object of the study: 463 patients with chronic lymphocytic leukemia (CLL), including 152 patients who were exposed to ionizing radiation (IR) due to Chornobyl NPP catastrophe (the main group), and 311 patients without IR exposure (the group of comparison). The aim: to determine the structure of IGHV genes in groups of CLL patients depending on radiation anamnesis, stereotypy of the B-cell receptor and homology with antibodies against the SARS-CoV-2 virus. Methods: clinical, molecular genetic (polymerase chain reaction, sequencing of the obtained reaction products), statistical. Equipment: thermocycler Bio-RadC1000 (N10450137), dispensers. It was established that the starting treatment was needed or CLL has progressed after COVID-19 infection in 53.8 % of patients with a previously established CLL diagnosis. Clinical features of de novo CLL, which developed in patients after COVID-19 infection, were determined. The high frequency of stereotyped cases (50.5 %) among examined CLL patients was shown. The distinctive features of stereotyped cases among IR-exposed CLL patients were characterized. Immunoglobulin sequences of 2.9 % CLL patients had homology with antibodies directed against auto-antigens, and of 8.5 % CLL patients had homology with antiviral antibodies, most often with anti-SARS-Cov-2 antibodies (2.4 %). Suggestions have been made about the possible impact of past infection of SARS-Cov-2 virus on the pathogenesis of CLL. In particular, an increase in the proportion of CLL cases with the expression of some stereotyped BCR and/or an increase of CLL risk in the long-term period after SARS-Cov-2 virus infection is not excluded. Product Description popup.authors Abramenko Iryna V. Martina Zoya V. Movchan Anna Vadymovna popup.nrat_date 2024-01-08 Close