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Information × Registration Number 0224U000600, 0119U100509 , R & D reports Title Clinical and pathogenetic and epidemiological features of acute infectious diseases and their complications in children, optimization of diagnosis and treatment popup.stage_title Head Lytvyn Galyna O., Кандидат медичних наук Registration Date 09-01-2024 Organization Danylo Halytsky Lviv National Medical University popup.description2  The conducted studies made it possible to establish the presence of a number of premorbid risk factors for the occurrence of purulent meningitis using the method of factor analysis. It has been shown that the activity of lactate dehydrogenase and the level of procalcitonin in the cerebrospinal fluid increase significantly more often in patients with purulent meningitis. In patients with serous meningitis, a significant activation of the Th2 immune response with pronounced production of anti-inflammatory cytokines by nervous system tissues and an increase in their levels in the cerebrospinal fluid was found. For the differential diagnosis of purulent and serous meningitis, the results of immunological studies of the cerebrospinal fluid and blood are of great value, namely: an increase in the level of tumor necrosis factor-? in the cerebrospinal fluid. The clinical features of infectious mononucleosis in children and differences in its course depending on the etiology of the disease are revealed. The high degree of adhesion of bacteria to the epithelial tissues of the tonsils, which was confirmed by the results of histological studies, is the basis for massive bacterial colonization in EBV tonsillitis with the formation of membranous layers. Better positive dynamics of the course of the disease were established in children who, in addition to standard therapy, received a complex drug containing lysozyme and pyridoxine hydrochloride. Based on the results of the conducted research, fundamentally new algorithms for the diagnosis of patients with meningitis have been developed, which allow to differentiate the purulent process from the serous process in the early stages of the disease, as well as to optimize the treatment of infectious mononucleosis in children. Product Description popup.authors Basa Natella Romanivna Hladchenko Olga Igorivna Dybas Iryna Volodymyrivna Klymenko Khrystyna Petrivna Lytvyn Halyna Orestivna Lyshenyuk Svitlana Adamivna Nadraga Oleksandr Bogdanovych Pokrovska Tetyana Valеriivna Prokopiv Oleksandra Volodymyrivna Sychkoriz Orest Jevgenovych Stasiv Mariya Vasylivna Khomyn Olena Yaroslavivna popup.nrat_date 2024-01-09 Close