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Information × Registration Number 0224U000619, 0122U002126 , R & D reports Title Role of TRP channels in visceral nociception and impaired smooth muscle contractility evoked by general anesthetics popup.stage_title Head Galaidych Oleg V., Кандидат біологічних наук Registration Date 10-01-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  We found that neurons of the rat spinal cord lamina X receive inputs from specific nociceptive afferents activated by TRPV1 receptors, the action of which can be suppressed by activation of TRPM8 receptors. We conclude that some anesthetics are able to inhibit spontaneous and/or carbachol-induced contractions of the small intestine and cause vasoconstriction, and that TRP channels, in particular TRPC4 of the ileum and TRPV4 of the pulmonary arteries, may be molecular targets. Product Description popup.authors Blaschak Ivan O. Galaidych Oleg V. Dryn Darіya O. Melnyk Mariia I popup.nrat_date 2024-01-10 Close