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Information × Registration Number 0224U000780, 0123U102873 , R & D reports Title Іntermittent hypoxia as a novel strategy for treatment/prevention of Alzheimer disease: molecular mechanisms and therapeutic implementation. popup.stage_title Head Serebrovska Zoia O., Кандидат біологічних наук Registration Date 12-01-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  This study investigates the beneficial impact of intermittent hypoxia on cognitive functions in humans and in an animal model of AD, exploring alterations in neuroinflammation, the expression of HIF1a, CYP2E1, and autophagy factors. Results demonstrate that brief and mild episodes of hypoxia improved cognitive functions in health and AD humans and enhanced spatial learning and memory in rats with STZ-induced AD-like pathology. This positive outcome coincided with an anti-inflammatory effect and an elevation in autophagy factors. Hypoxic-hyperoxic interval training could be considered a promising mild non-pharmacological approach for alleviating memory impairment symptoms in AD. Product Description popup.authors Hryb Oksana M Gushcha Valeria V. Maksymchuk Oksana V. Porkhalo Denys F Savchenko Anton V. Serebrovska Zoia O. Tumanovska Lesia V. Hetsuriani Mykhaylo R. Kholin Viktor O. Shysh Anzhela M. popup.nrat_date 2024-01-12 Close