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Information × Registration Number 0224U000795, 0119U001142 , R & D reports Title The role of exogenous and endogenous sulfur-containing compounds in mechanisms of internal organs damage and cytoprotection at different pathological conditions popup.stage_title Head Zaichko Nataliia V., Доктор медичних наук Registration Date 12-01-2024 Organization Vinnytsia National Pirogov Memorial Medical University popup.description2  The conducted studies allowed to establish the role of modulators of the processes of trasulfuration, desulfuration, oxidative pathways of hydrogen sulfide and sulfur-containing amino acids in molecular mechanisms of the various pathological conditions development (obesity, diabetes, thyroid endocrinopathy, chronic kidney disease, and renal failure), identify new biochemical factors capable of regulating the metabolism of biologically active sulfur-containing compounds (thyroxine, calcitriol, mediators of apoptosis, fibrosis and inflammation, growth factors, chronic hyperglycemia, hyperazotemia), experimentally substantiate new approaches to endothelio-, cardio, and nephroprotection by correctors of hydrogen sulfide metabolism. Inhibitors of hydrogen sulfide formation (propargylglycine, homocysteine thiolactone) deepened adverse changes and potentiated the development of associated pathobiochemical disorders. Metabolic correctors of H2S levels (genistein, lipoic acid, sodium thiosulfate, taurine, zinc sulfate, metformin) showed antioxidant, antiapoptotic, antifibrotic effects. Therefore, when studying the pharmacotherapeutic effectiveness and mechanisms of action of potential cardio-, endothelio-, and nephroprotectors, it is advisable to determine their influence on various links of sulfide metabolism in organs and tissues, and to give preference to agents that, along with the targeted therapeutic effects, are able to adjust the level of endogenous hydrogen sulfide under various pathological conditions. Product Description popup.authors Ilchenko Olexandr Volodimirovich Blazhchenko Vitaliy Viktorovych Bobetska Olena Pylypivna Voloschjuk Nataliia Ivanivna Kachula Sergii Olexandrovich Koniukh Serhii Anatoliiovych Melnyk Andrii Volodimirovich Andrii V. Melnyk Nechiporuk Vitaliy Ostreniuk Roman S. Palamarchuk Iryna Vitaliivna Samborska Inha Anatoliyivna Strutynska Olena Borisivna Filchukov Denis Olexandrovich Shtatko Olena Ivanivna popup.nrat_date 2024-01-12 Close