Search academic texts

Information × Registration Number 0224U000889, 0122U002132 , R & D reports Title Identification of sites of the molecular interactions of fibrin(ogen) molecule. popup.stage_title Head Chernyshenko Volodymyr O., Доктор біологічних наук Registration Date 14-01-2024 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2  Fibrinogen is an important protein of the hemostasis system, which, turning into fibrin, acquires the ability to polymerize and forms the basis of a blood clot - a thrombus. It is the molecular transformations and intermolecular interactions of fibrinogen that underlie extraudinal intravascular The functional role of individual sections of the Aα-chain of fibrin(ogen) was delineated. A high-affinity interaction site with plasminogen is present in the Aα414-504 region, and the important role of the region in the process of maintaining platelet aggregation is shown. It was found that the Aα505-610 region is important for the construction of protofibrils, activation of plasminogen, maintenance of the viability of endotheliocytes, as well as the migration of cancer cells. Product Description popup.authors Hrabovskyi Oleksii Olehovych Stohnii Yevhen M. Yatsenko Tetiana Andriivna popup.nrat_date 2024-01-14 Close