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Information × Registration Number 0224U000946, 0123U100471 , R & D reports Title To develop an algorithm for immunological and molecular genetic monitoring of patients with Ph-negative myeloproliferative neoplasms in the induction of remission and in patients with Ph-positive chronic myeloid leukemia, who achieved remission with targeted drugs. popup.stage_title Head Voroniak Myroslav I., Кандидат біологічних наукMasliak Zvenyslava V., Доктор медичних наук Registration Date 15-01-2024 Organization State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine" popup.description2 During thіs stage of work, the method of identifying the residual population of leukemic stem cells (LSC) with the CD34+CD38-CD26+ CD45+ immunophenotype in the group of CML patients in molecular genetic remission was developed. Twenty four patients with deep molecular response - MR4, MR4, MR5 - were selected for immunological and molecular genetic monitoring. Of the 7 people who stopped taking ITC, 4 people remain in the status of stop treatment. Immunological and molecular genetic monitoring of 17 patients - candidates for treatment termination - is ongoing. The second group included 10 patients with myelofibrosis receiving targeted therapy with the JAK2 inhibitor ruxolitinib. The monitoring of the allelic load of the JAK2 driver gene is performed, the observed reduction was 34-66%. The entire examined group of MF patients continues treatment and monitoring of response every 3 months. Product Description popup.authors Boyko Olha I. Danysh Olha Yo Dzis Ivan Ye Kokoruz Maryana V Kotlyarchuk Kostyantyn B Luchka Liliya O Melnyk Mariya I Simonova Maryana I Tomashevska Nataliya Ya Thir Hrystyna R Hudzii Sofia S Shelep Natalia V. Shurko Nataliia O popup.nrat_date 2024-01-15 Close