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Information × Registration Number 0224U001004, 0119U000324 , R & D reports Title Drug-resistant pulmonary tuberculosis: new technologies to detect resistance in Mycobacterium tuberculosis and prevalence of aquired drug resistance to key anti-tuberculosis medicines popup.stage_title Head Dudnik Andrii B., Registration Date 16-01-2024 Organization Ministry of Health of Ukraine popup.description2  Research report: 123 pages, 14 tables, 11 figures, 71 references. LINE PROBE ASSAY, GENETIC MUTATIONS, MOLECULAR DIAGNOSTIC METHODS, DRUG-RESISTANT TUBERCULOSIS, ACQUIRED DRUG RESISTANCE, PATIENTS’ EXPENDITURE The object of the study is a drug-resistant pulmonary tuberculosis. The aim of this study is to develop a new molecular test for detection of M/XDR-TB and to determine the prevalence of acquired resistance to key anti-TB drugs among new and retreated TB cases. Research methods: clinical, laboratory, questionnaire, statistical. What This Study Adds to the Field: high diagnostic accuracy of LPA varied from 78.4% (moxifloxacin) to 95.2% (isoniazid and capreomycin) when testing culture isolates in comparison with conventional DST. The performance of LPA testing on clinical samples may contribute to the optimal distribution of wards between patients with different resistance profiles and to reduce the time under empirical TB treatment. In comparison with testing only with XpertMTB/RIF, LPA may identify over half of those patients that are not eligible due to profile of resistance to a short treatment regimen with an injectable agent. A third of TB patients in Ukraine in 2013-2014 had acquired drug resistance to at least one of the key anti-TB drugs (H, R, FQ or SLIs). Acquired drug resistance reduced the probability of sputum culture conversion by 70% and increased the probability of reversion by 2.4 times. Ambulatory TB management costs almost 2.5 times lower compared to the hospital-based treatment. Implementation: 1 draft of regulatory document was prepared, publications: 1 monograph, 10 articles and/or abstracts, 2 methodological publications; 15 scientific presentations, 3 international online courses. The field of application is Phthisiology (tuberculosis, respiratory medicine). How to receive the report: on reasonable request to National Pirogov Memorial Medical University, Vinnytsya; 56, Pyrogova St, Vinnytsia, Ukraine, 21018. Product Description popup.authors Dudnyk Andrii Kulyk Liudmyla Lytvyniuk Oksana popup.nrat_date 2024-01-16 Close