Search academic texts

Information × Registration Number 0224U001033, 0121U107508 , R & D reports Title 620. Personalization of the treatment and development of new biologically active substances in optimization of pharmacotherapy of a few socially important diseases popup.stage_title Head Antonenko Petro В., д.мед.н. Registration Date 16-01-2024 Organization Odessa National Medical University popup.description2  In patients with pulmonary tuberculosis with the *1G/1G genotype, the activity of alanine aminotransferase and aspartate aminotransferase increased during antituberculosis treatment by 72.7% (р=0.033) and by 115.8% (р=0.049), respectively, which indicates an increased risk of developing hepatotoxicity in carriers of the specified genotype. Intravenous administration of Ig G for 20 months in HIV-positive patients with drug-resistant tuberculosis with a level of CD4+ <50 cl/μl, is associated with smear conversion in 84.6% of patients, disappering of focal and infiltrative changes in the lungs - in 53.8% of patients (p < 0.05), an increase in the content of CD4+ lymphocytes in the blood by 27.0%, compared to the control group; in addition, the level of recovery in the main group was 80.8% comparatively to 53.8% of patients in the control group (p<0.05). Current research are fulfilled according to planning task of Ministry of Health of Ukraine Product Description popup.authors Al Nadavi Nora Antonenko Kateryna Antonenko Petro Kaprosh Antonina Kresyun Valentyn Lobashova Katerynа Matsegora Nina Ostapchuk Katerynа Poludenko Hanna Prystupa Bohdan Rozhkovsky Yaroslav Shemonayeva Katerynа Yunusova Saida popup.nrat_date 2024-01-16 Close