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Information × Registration Number 0224U001353, 0123U101545 , R & D reports Title To study the effectiveness of percutaneous interventions in patients with chronic coronary syndromes and various clinical manifestations, depending on the results of non-invasive, invasive and intravascular diagnostics of coronary arteries under stress caused by military aggression popup.stage_title Head Sokolov Maksym Yu., Доктор медичних наук Registration Date 22-01-2024 Organization State Institution "National Scientific Center "The M.D. Strazhesko Institute of cardiology, clinical and regenerative medicine named after academician of the National Academy of Medical Sciences of Ukraine" popup.description2  The researchers have introduced a methodology for conducting dosed exercise testing using new high-tech methods of electrocardiogram analysis (HF-QRS (Hyper-Q) algorithm), which provides more effective diagnosis of patients at high risk of coronary heart disease in the absence of traditional signs of ischaemia. It has been proven that the sensitivity compared to coronary angiography is 70.6% and the specificity is 41.17%, which is insufficient and requires invasive coronary interventions to clarify further medical care tactics for such patients. In 43.75% of patients, the determination of FFR leads to a change in the treatment strategy determined by angiography, in particular, in 25% of cases, interventional percutaneous intervention is required, and in 75% of patients, such stenoses are haemodynamically insignificant and require lifestyle modification and optimisation of pharmacotherapy. The study proved that intracoronary imaging using intravascular ultrasound allows to clarify the length of the lesion, reveals a higher frequency of atherosclerotic plaques with signs of severe fibrosis (25.0%, p<0.05), their surface (25.0%, p<0.05) and deep calcification (21.9%, p<0.05) compared with lipid plaques (12.5%) in the coronary arteries of the examined patients under stress caused by armed aggression, which requires a change in the tactics of percutaneous coronary interventions, in particular the use of high-pressure balloons and noncompliant balloons. The study shows that the use of IVUS allows optimising stent implantation, in particular, in 20.0% of cases, stent malposition is detected, which requires angioplasty using high-pressure balloons and noncompliant balloons. Product Description popup.authors Vlasova Olena M Garazdiuk Oleksandr I Kashuba Yulia V popup.nrat_date 2024-01-22 Close