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Information × Registration Number 0224U001782, 0120U105157 , R & D reports Title Mechanisms of development of vascular and neurological complications in patients with diabetes mellitus and metabolic syndrome. popup.stage_title Head Zherdova Nadiia M., Доктор медичних наук Registration Date 30-01-2024 Organization State Scientific Institution "Center for Innovative Medical Technologies of the NAS of Ukraine" popup.description2  At the stage of the study, patients with newly diabetes mellitus (DM), prediabetes and diabetes mellitus type 2 were examined to determine the risk factors for vognitive impairment, the presence of cardiac autonomic neuropathy(CAP), diabetic peripheral neuropathy, state of the antioxidant system, the level of mRNA HIF-1 and BDNF and the effect of metformin on these parameters, the study of the incidence of depressive disorders in patients with obesity and liver fibrosis. During the reporting period, the results were presente at scientific and practical conferences at the international and domestic levels. Summarizing the results of this study, we can conclude that cognitive impairment is a common complication of both pre-existing diabetes mellitus and newly diagnosed diabetes mellitus2. Thus, for type 1 diabetes is from 54.5% to 63.6%, among patients with type 2 diabetes - from 20.0% to 96.7%, for newly diagnosed - 8.3% to 96.7 % depending on the tests performed to assess cognitive impairment. Risk factors for the development of cognitive dysfunction in patients with type1 diabetes mellitus: the age of the patient at the time of diagnosis, increase body mass index, the presence of hypoglycemic conditions and diabetic retinopathy. In patients with DMD 2 types of mature age, the negative factors leading to cognitive dysfunction include an increase in the duration of the disease, a high level of glycosylated hemoglobin, the presence of hypoglycaemic states, high levels of total cholesterol, the presence of diabetic peripheral neuropathy (DPN), diabetic retinopathy (DR), depression disorders. In infants - there is an increase in age of patients, male sex, increased glycosylated hemoglobin, increase in body mass index, presence of depression, DPN, DR, increase level systolic and diastolic blood pressure. The incidence of depression among patients with obesity and fibrosis was 50%. Product Description popup.authors ISKANDAROVA ELONA А. BAKA OLENA M. Kopchak Oksana O. MANKOVSKYI BORYS М. Orlyk Olga S. Saienko Ianina A. SAKHAROVA YULIIA V. STEPURA OLENA A. KHODANONOK STANISLAV V. KHORIEVINA KATERYNA M. popup.nrat_date 2024-01-30 Close