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Information × Registration Number 0224U002235, 0121U111449 , R & D reports Title To investigate the patterns of expression of cellular and molecular markers by lymphocytes and tumor cells to assess violations of antitumor immunity in patients with acute myeloid leukemia. popup.stage_title Head Hordiienko Alla I., Доктор біологічних наук Registration Date 09-02-2024 Organization State Institution "Institute of Hematology and Transfusiology of the National Academy of Medical Sciences of Ukraine" popup.description2 The object of the study is 18 patients with acute myeloid leukemia (AML) in the first acute period before and after specific treatment. The purpose of the work is to investigate the intensity of expression of the CD28 receptor on CD3+ T-lymphocytes and costimulatory molecules of the B7 family (B7.1/CD80, B7.2/CD86) on a clone of tumor cells and monocytes; to study indicators of adaptive, innate immunity and clinical and hematological features in patients with AML in the first acute period before the start of treatment and after specific therapy. It was established that before the start of treatment, AML patients have a low level of intensity of expression by PC tumor cells with an immunophenotypic profile of CD34+, CD117+, CD33+ costimulatory molecules of the B7 family (B7.1/CD80, B7.2/CD86). It was shown that in patients with AML, before the start of treatment, the number of CD3+- T-lymphocytes with a low level of intensity of co-expression of the CD28+ ligand, which disrupts the intensity of immune reactions, is increased in the peripheral circulation. CD33+- monocytes with a high level of expression of costimulatory molecules CD80+-, CD86+- and T-lymphocytes with CD28+- ligand, which were found in the peripheral blood, are positive factors in controlling the duration of remission. It is shown that one of the reasons for the imbalance of antigen-specific antitumor immunity in patients with GML before the start of therapy is a decrease in the number of CD3+-, CD3+CD4+-, CD3+CD8+- T-lymphocytes in PC. Medical and social effect. Medicine. Product Description popup.authors Aladieva Olena M. Hordiienko Alla I. Starodub Halyna S. Tretyak Nataliia M. popup.nrat_date 2024-02-09 Close