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Information × Registration Number 0224U002338, 0122U001818 , R & D reports Title Hybrid nanosystems based on "smart" polymers for biotechnology and medicine popup.stage_title Head Kutsevol Nataliia V., Доктор хімічних наук Registration Date 12-02-2024 Organization Taras Shevchenko National University of Kyiv popup.description2 Research object – Multicomponent nanosystems based on "smart" polymers and hydrogel materials with incorporated biologically active nanoparticles of metals, metal oxides, and medicinal preparations. Research subject – Creation of highly effective polymer-based nanosystems for minimally invasive methods in oncology; hydrogel materials with high antibacterial activity for the treatment of wounds of various genesis; as well as highly sensitive nanocomposites for new imaging methods in biotechnology and medicine. Research methods – Gel permeation chromatography, transmission electron microscopy (TEM) and scanning microscopy (SEM), dynamic light scattering (DLS), NMR, UVvis. and IR spectroscopy, photoluminescence, in vitro and in vivo testing. The dextran-polyacrylamide copolymer in nonionic and anionic forms and the thermosensitive polymer dextran-poly-N-isopropylacrylamide were synthesized and characterized. Multicomponent nanosystems in polymer matrices with incorporated nanoparticles of Au, Ag, ZnO and drugs were synthesized and studied. It was established that nanocomposites with anticancer drugs showed high efficiency in comparison with free anticancer drugs. Hydrogels based on Dextran-Polyacrylamide and Chitosan-Polyacrylamide graft copolymers were synthesized and studied. Differences in the physicochemical characteristics of synthesized hydrogels and composites based on them were established. It has been proven that nanocomposite hydrogels with Ag nanoparticles and drugs have higher antibacterial activity than classical antiseptics. A series of new quinoline-based model compounds, which may be promising for biomedical applications, have been synthesized and investigated.  Product Description popup.authors Yeshchenko Oleh А. Virych Pavlo A. Kuziv Yuliya I. Nadtoka Oksana M. Vadym O. Pavlenko Smokal Vitaliy O. Kharchenko Oksana H. Chumachenko Vasyl A. popup.nrat_date 2024-02-12 Close