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Information × Registration Number 0224U002351, 0120U105605 , R & D reports Title Development of the novel immunoenzymatic technologies for diagnosing B-cell lymphoid neoplasms and their practical implementation popup.stage_title Head Filchenkov Oleksii O., к.б.н. Registration Date 12-02-2024 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 The atypical expression of the antigens CD90, CD117, and CD123 has been shown on cells of peripheral blood of 34 patients with different forms of non-Hodgkin lymphomas. At least one of these antigens was detected on no less than 1% of cells in subpopulation of CD45-positive malignant lymphocytes in 20–33.3% of the mantle cell lymphoma cases and 27.2–54.5% of the marginal zone lymphoma cases. One case of mantle cell lymphoma demonstrated a high percentage of CD117-positive cells with the accompanying CD90 expression on 3.8% of malignant lymphocytes. Cells of various mature B-cell neoplasms including continuous lymphoma cell lines express ubiquitously CD147 except for plasma cell neoplasm. CD150 has been suggested as immunophenotypic marker of marginal zone lymphoma cells with its expression correlating with CD19, CD20, and CD79b expression. The CD150 expression is a characteristic feature of plasma cells in the bone marrow of multiple myeloma patients accounting for 42.6–69.8% of cells in the CD45–CD38+CD138+ subpopulation. In all studied cases of multiple myeloma, CD150 is coexpressed both with CD38 and CD138. Therefore, CD150 may be considered as an auxiliary marker for immunological phenotyping of malignant cells aimed at the improvement of the laboratory diagnosis of the mature B-cell lymphoid neoplasms accounting for the criteria of the new WHO classification (2022). Product Description popup.authors Hordiienko Inna M. Zavelevych Mykhailo P. Petrus Nataliia O. Polishchuk Alona S. Poludnenko Liudmyla Yu. Shlapatska Larysa M. popup.nrat_date 2024-02-12 Close