Search academic texts

Information × Registration Number 0224U002369, 0118U007346 , R & D reports Title Functional characteristics of the spinal cord neurons and their changes under various pathologies and injuries. popup.stage_title Head Romanenko Sergii Vyacheslavovich, Registration Date 12-02-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  This scientific work delves into the complex dynamics of afferent-driven presynaptic inhibition (AD-PI) in the spinal cord, focusing on critical areas of lamina I and lamina X involved in nociceptive information processing. The study employs selective activation of unmyelinated C-fibers, revealing novel insights into pain processing through detailed examination of fiber types. The research highlights the significant impact of AD-PI on neurons in lamina I, traditionally associated with nociceptive input processing, and lamina X, emphasizing the crucial role of Aβ/δ fibers in modulating pain-related information. Additionally, the study emphasizes the importance of these fundamental mechanisms in shaping afferent input to neurons and contributing to the complex network involved in spinal nociceptive processing. Furthermore, the work provides valuable insights into the role of T-type calcium channels in peripheral diabetic neuropathy, offering avenues for further exploration of spinal cord function in pain perception. Product Description popup.authors Bagatska Olena V. Halaidych Oleh V. Duzhyi Dmytro Ye. Koroid Kostiantyn V. Kostiuk Olha I. Mitruzaeva Valeria A. Medvyedyev Volodymyr V. Pivneva Tetiana A. Romanenko Serhii V. popup.nrat_date 2024-02-12 Close