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Information × Registration Number 0224U002464, 0120U103066 , R & D reports Title The investigation of the involvement of resident T-memory cells in the pathogenesis of chronic inflammatory dermatoses popup.stage_title Head Kondakova Hanna K., Кандидат біологічних наук Registration Date 15-02-2024 Organization State institution "Institute of Dermatology and Venereology of NAMS of Ukraine" popup.description2 The study of the pathophysiology of psoriasis revealed a number of molecular genetic factors that initiate a chronic inflammatory response in psoriasis. The analysis of variants of the distribution of genotypes of the TLR1-I602S and NLRP1 (rs878329) single-nucleotide polymorphisms, as well as the detection of the frequency of the HLA-Cw*06 and HLA-B*27 genes, taking into account the severity of psoriasis, made it possible to form risk groups for the progression of the pathology. The detected changes in immunological indicators in psoriasis and psoriatic arthritis indicate the presence of general and intergroup differences. In patients with a severe course of dermatosis (psoriatic arthropathy) in the progressive stage, a lower expression of anti-inflammatory cytokines IL-4 and IL-10 was noted against the background of a significant increase in the level of pro-inflammatory cytokines, especially IL-1β, IL-7 and IL-17a, which indicates development of insufficient regulatory capacity of the immune system. An immunohistochemical study of the subpopulation and quantitative composition of resident memory T cells in the skin of patients with psoriasis showed that in the lesions of the skin, resident memory T cells are concentrated in the papillae of the dermis at the border with the epidermis and in the epidermis itself, as well as in the dermis - in the perivascular spaces at the base of the papillae. Inflammatory lymphocytic infiltration is represented by CD3+, CD4+, CD8+ lymphocytes with a predominance of CD8-positive T-lymphocytes and, accordingly, a change in the CD4+/CD8+ ratio during the exacerbation of the disease. Product Description popup.authors Vitkovska Mariia O. Hoidenko Nataliia I. Holub Hanna P. Kurylo Nataliia B. Mashtakova Iryna O. Oliinyk Iryna O. Sokol Oksana A. popup.nrat_date 2024-02-15 Close