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Information × Registration Number 0224U002551, 0123U100100 , R & D reports Title Hormonal-receptor status of tumor microenvironment cells as a factor in the modulation of oncogenesis in the endometrium and breast cancer popup.stage_title Head Buchynska Liubov H., Доктор біологічних наук Registration Date 18-02-2024 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 Partner proteins encoded by genes (SRC, CCND1, TP53, PGR, FN1, HIF1A, AKT1) associated with ESR1 (score > 0.9) were identified, which are important for the progression of such hormone-dependent neoplasms as endometrial cancer (ЕС) and breast cancer mammary (BC). It was established that low mRNA expression of CCND1, TP53, PGR and high SRC, FN1 in EC tissue and low CCND1, PRG and high TP53, SRC and FN1 in BC tissue are associated with an unfavorable course of the disease. In patients with EC, molecular phenotypes were determined based on the expression of steroid hormone receptors, which correlates with the level of proliferative potential, the content of ER+-fibroblasts in the stromal component of the neoplasm, and the stage of the tumor process. Tumors of patients with the I-II stage of the disease were characterized by heterogeneity according to the above indicators, which allowed us to hypothesize the role of the content of ER+-fibroblasts in determining the proliferative plasticity of endometrial carcinomas at these stages of the disease. It was found that the phenotype of endometrial tumor cells based on the expression of steroid hormones, the morphological desmoplastic variant of the stromal component and the content of the subpopulation of ER+-fibroblasts largely determine the aggressiveness of the tumor process in the endometrium. Product Description popup.authors Hlushchenko Nadiia M. Hordiienko Inna M. Madiar Bohdana D. Yurchenko Nataliia P. popup.nrat_date 2024-02-18 Close