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Information × Registration Number 0224U002655, 0118U000359 , R & D reports Title Purposeful search for biologically active substances in the series of 7,8 - disubstituted theophylline; Pharmaceutical analysis, standardization and bioanalytical research of antihypertensive drugs using chromatographic methods popup.stage_title Head Korobko Dmytro B., Registration Date 23-02-2024 Organization Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine popup.description2  Report on the GDR: 134 pp., 65 tables, 28 figures, 80 sources. 7,8-Disubstituted 1,3-dimethylxanthine, chemical interaction of 7-R-8-hydrazino-theophyllines with 2-oxopentanedioic acid, physical and chemical properties of compounds; antihypertensive drugs, validation, HPLC/MS/MS, "biowaver" procedure. The object of the study is condensed derivatives of 7-alkyl-(benzyl-, 2-phenoxy-ethyl-)-8-hydrazinotheophylins, 2,2-diphenyl-1-picrylhydrazyl; antiradical activity; antihypertensive drugs (amlodipine, enalapril, bisoprolol): substances and tablets of industrial and experimental production; blood plasma; a monolayer of CaCO-2 cells. The purpose of the research: synthesis of a series of new functional derivatives of 7-R-8-hydrazinotheophylins, establishment of some physical and spectral characteristics for the obtained substances, identification of lead compounds with an antiradical action profile; development of a bioanalytical method for the determination of bisoprolol and enalapril in the presence of enalaprilat in plasma; Product Description popup.authors Ivanusa Iryna B. Horlachuk Nataliia V. Zarivna Nadiia O. Kryskiw Liubomyr S. Kucher Tetiana V. Lohoida Lilia S. Mykhalkiv Mariia M. Mosula Liudmyla M. Peleshok Kateryna Ye. Poliak Olha B. Shulyak Nataliia S. popup.nrat_date 2024-02-23 Close