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Registration Number

0224U002803, 0120U105603 , R & D reports

Title

To study the peculiarities of dysfunctional state of adipose tissue that form the metastatic potential and determine the tumor progressing

Head

Hanusevych Iryna I., Доктор біологічних наук

Registration Date

01-03-2024

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Description

 Dysfunction of the electron transport chain of mitochondria, which is characteristic of the surrounding adipose tissue, deepens under the influence of oxidative metabolic products of sex hormones and is a factor that influences on the tumor microenvironment. It has been established that obesity, taking into account age and gender gastrointestinal cancer (GC) patients and menopausal status breast cancer (BrC) patients, is associated with an aggressive tumor microenvironment, in particular, with high level of superoxide radical (SR) generation, the number of tumor-associated adipocytes (TAAs), matrix metalloproteinases-2 and -9 (MMP-2 and -9) activity and ribonuclease (RNase) activity, and low levels of ornithine decarboxylase (ODC) activity. These indicators are related to distant metastasis and/or patient survival, and are defined as promising markers of the cancer course of overweight patients.

Product Description

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Bubnovskaya Larysa M.
Burlaka Anatolii P.
Virko Serhii V.
Verbynenko Alla V.
Samoilenko Helena A.
Shlyakhovenko Volodymyr O.