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Information × Registration Number 0224U002858, 0118U005468 , R & D reports Title The role of remodeling markers of bone tissue in the formation of the degree of malignancy of the most common hormone-dependent tumors popup.stage_title Head Lukianova Nataliia Yu., Доктор біологічних наукChekhun Vasyl F., Доктор медичних наук Registration Date 07-03-2024 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 For the first time in experiments in vitro, the participation of bone tissue remodeling proteins in the formation of the malignancy degree in cells of the most common hormone-dependent neoplasms has been proven. A significantly higher level of osteonectin (ON) expression was identified in BC hormone-refractory cells (MDA-MB-231 and MDA-MB-468) and PCa (DU-145) cell lines, which were characterized by high proliferative and invasive activity, as well as low adhesiveness. Ex vivo on clinical material for the first time, the significance of expression of bone tissue remodeling markers in tumor cells for in-depth characterization and prognosis of BC and PCa was substantiated. The highest levels of OPN and ON expression were recorded in BC tissue with metastatic lesions of regional lymph nodes, a low degree of differentiation and a basal molecular subtype, which is characterized by an aggressive course. Overall 5-year survival of BC patients with high levels of OPN is 20% lower. It was established that OPN expression correlated with such clenecal parameters of PCa as the presence of metastases in regional lymph nodes and distant metastases, Gleason grading and preoperative PSA level in blood serum. The relapse-free 3-year survival rate of PCa patients is significantly lower in the presence of a high level of OPN and ON expression (by 25% and 30%, respectively). Dysregulation of the expression of markers of bone tissue remodeling in the cells of hormone-dependent neoplasms of a high malignancy degree causes a significant imbalance of pro- and anti-inflammatory cytokines (IL-6 and IL-10) in the blood and is associated with a decrease in the adhesive properties of malignantly transformed cells. Results are the basis for the development of new criteria for predicting the course of the tumor process and the improvement of existing treatment schemes for the most common hormone-dependent malignant neoplasms, taking into account the expression of markers of bone tissue remodeling Product Description popup.authors Borikun Tetiana V. Voronina Olena K Haluzinskyi Oleksandr A. Hohol Sergii V. Hrybach Serhii M. Zadvornyi Taras V. Konovalenko Volodymyr F. Kunska Liubov M. Mushii Oleksandr M. Nalieskina Lesia A. Pavlova Anna O. Ternovyi Mykola K. Tuz Yevhen V. Shepelenko Iryna V. popup.nrat_date 2024-03-07 Close