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Information × Registration Number 0224U002890, 0119U002907 , R & D reports Title Chemico-pharmaceutical substantiation of the creation of biological-active compounds, conjugates and drug compositions with anti-inflammatory and anti-pain activities popup.stage_title Head Syrova Hanna O., д.фарм.н. Registration Date 12-03-2024 Organization Kharkiv National Medical University popup.description2  Spatial, energetic and electronic characteristics of molecules of NSAIDs of the coxib group (rofecoxib and celecoxib) were determined using Quantitative Structure Activity Relationship (QSAR) quantum chemistry methods. Experimental studies of the pharmacological activity (anti-inflammatory, analgesic) of coxibs of different chemical structures (celecoxib and rofecoxib), caffeine, lycopid and pharmaceutical compositions of coxibs with caffeine and coxibs with lycopid, the conjugate of NSAIDs (mefenamic acid) with diaminocalixarene (bis-mefenamidocalixarene) were carried out. ALS in a series of 1,2,4-triazole derivatives and their pharmaceutical compositions with caffeine and lycopid in laboratory animals (sexually mature rats of the WAG line) with intragastric administration (in/shl) in the model of "formalin edema" (FN), using the General program Unrestricted Structure-Activity Relationships (GUSAR-online) established the toxicity of 14 compounds of 1,2,4-triazole derivatives; also studied the effect of pharmaceutical compositions of coxibs (celecoxib, rofecoxib) and caffeine and lycopid on the mnestic activity of rats under the conditioned passive avoidance response (PVR) and on the emotional-behavioral response (EPR) in the "open field" test on the FN model. The influence of experimental coxibs and their pharmaceutical compositions with adjuvants on biochemical indicators of the inflammatory process was determined: diene conjugates (DC), sialic acids (SC), ceruloplasmin (CP) in the blood of rats on the background of FN (biochemical studies). Analgesic activity (ANA) was studied by its influence on the central (on the FN model) and peripheral (on the "acetic acid spasms" model) components of the pain reaction. Product Description popup.authors Kozub Svitlana M. Levashova Olha L. Lukyanova Larysa V. Prysiazhnyi Oleksandr V. Saveliyeva Olena V. Tishakova Tetiana S. Chalenko Nataliia M. popup.nrat_date 2024-03-12 Close