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Information × Registration Number 0224U003067, 0121U113840 , R & D reports Title Study of the lactobacilli, bifidobacteria and opportunistic pathogens of the human microbiota influence on the features of mechanisms realization of metabolic disturbances in the tumor process (2.2.5.447) popup.stage_title Head Lykhova Oleksandra O., Кандидат біологічних наукChekhun Vasyl F., Доктор медичних наук Registration Date 03-04-2024 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  Lactobacillus rhamnosus and Bifidobacterium animalis cause metabolic reprogramming of the studied human breast cancer cells, influencing not only the biochemical links of glucose metabolism but also signaling pathways modulating the IR expression level. Exposure of breast cancer cells with opportunistic human microbiota members Staphylococcus and Pseudomonas species leads to a statistically significant increase in ROS production in all studied cell lines. The studied bacterial cells induce oxidative stress in human breast cancer cells of the luminal subtype, but malignant cells use glycolysis and the Warburg effect to neutralize this effect of microorganisms. Thus, it has been proven that the influence of both saprophytic and opportunistic bacteria causes significant changes in various links of the metabolic processes of malignant cells, which can be one of the key stages of the initiation of oncosynergistic processes during the progression of tumor disease. Product Description popup.authors Bezdieniezhnykh Nataliia O. Virych Petro A. Kozak Tamara P. Konovalenko Serhii V. Kukurudza Dmytro V. Lukіanova Elizaveta D. Lupan Valentyna H. Neborets Anastasiia D. Todor Ihor M. Khaietskyi Ihor K. Shvets Yuliia V. Shvets Yuliia V. popup.nrat_date 2024-04-03 Close