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Information × Registration Number 0224U031502, 0123U100111 , R & D reports Title Development of the diagnosis and prognosis method of the tumors progress using carcinoembryonic antigen-related cell adhesion molecules and cyclooxygenases popup.stage_title Head Sikora Vladyslav V., Кандидат медичних наук Registration Date 03-05-2024 Organization Sumy State University popup.description2  The subject of the research is the molecular-genetic characteristics of malignant tumors in primary locations. The research focuses on the immunophenotyping of cells in malignant tumors and tumor-infiltrating immune cells, elucidating the pathogenetic features of the interaction between checkpoint inhibitors and control points, and investigating the effectiveness of using immune checkpoint inhibitors in modifying the course of malignant neoplasms. The objective of the study is to establish the correlation between the molecular-genetic characteristics of tumors and their progression, and to develop a methodology for inhibiting tumor growth using antibodies to carcinoembryonic antigen molecules and cyclooxygenase blockers. To achieve the set goal, the following tasks were defined: to conduct immunohistochemical research of tumor tissue regarding the expression of CEACAM -1, -5, -6, -7, -20 and COX-1, -2; to identify the immunoprofile characteristics of neoplastic tissue in "cold" and "hot" tumors; to determine the impact of CEACAM-1, -5, -6, -7, -20 and COX-1, -2 expression on tumor progression; to investigate the qualitative characteristics (mass, structural modifications) of proteins in intact and neoplastic cells; to determine the presence of gene polymorphisms encoding CEACAMs and COX. Research methods include histological and immunofluorescent tissue studies; protein and DNA/RNA extraction from cells and tissues; enzyme-linked immunosorbent assay; polymerase chain reaction; and mathematical methods. The research aims to establish the immunophenotype of intact and tumor tissues, determine the uniqueness of their protein-genetic composition, and investigate the involvement of proinflammatory cytokines in the variability of molecular-genetic characteristics of cells Product Description popup.authors Hyriavenko Nataliia І. Dryhval Bohdan O. Kravchenko Yaroslav O. Lyndin Mykola S. Lyndina Yuliia M. Sikora Vladyslav V. Sikora Kateryna O. Smorodska Olha M. Sokura Victoriia A. Stroi Elizaveta A. Tsepochko Dariia H. Yanko Illia K. popup.nrat_date 2024-05-03 Close