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Information × Registration Number 0224U032156, 0116U005346 , R & D reports Title The activity of endogenous antimicrobial peptides in children with acute and recurrent respiratory diseases popup.stage_title Head Леженко Геннадій Олександрович, Registration Date 31-07-2024 Organization Zaporizhzhya State Medical University popup.description2 It is established that the development of severe bronchitis in 74.3% is due to the colonization of the respiratory tract by bacterial flora. The leading etiological factor in the development of bacterial acute bronchitis in young children are gram-negative bacteria Haemophilus influenzae, and in development. community-acquired pneumonia - gram-positive bacteria Streptococcus pneumoniae. It is proved that the development of acute bronchopulmonary diseases, especially their severe forms, in young children occurs against the background of low levels in the serum of LL-37, β1-defensin, hBPI and activation of lactoferrin synthesis. A significant pathogenetic factor of insufficient activation of these antimicrobial peptides is a deficiency of vitamin D metabolites, which, combined with a decrease in vitamin D-binding protein, was one of the pathogenetic links in the formation of severe disease. The most significant changes are characteristic of children with acute bronchitis caused by Haemophilus influenzae and patients with pneumococcal pneumonia, in which in most cases the severe course of the disease prevailed. It was found that acute respiratory infections of bacterial etiology were accompanied by the development of anemia of inflammation, which was characterized by activation of the first link of the apoptosis process, as evidenced by increased serum caspase-9 in patients with acute bacterial respiratory diseases compared with the control group. The highest levels of caspase-9 were observed in children with pneumonia. It is proved that effective activation of the effector part of the caspase "cascade" (caspase-7) in children with acute bacterial respiratory diseases was not observed, which may indicate the ineffective nature of apoptosis and other involved effector pathways of its activation. Product Description popup.authors Hyria Olena M. Krainia Hanna V. Lebedynets Oleksandra M. Pashkova Olena Ye. Pohribna Anastasiia O. Reznichenko Yurii H. Samoilyk Kateryna V. Yartseva Mariia О. popup.nrat_date 2024-07-31 Close