Search academic texts

Information × Registration Number 0224U032199, 0120U103997 , R & D reports Title Measurement of redox potentials (ORP) of N-substituted p-quinone imines by direct potentiometry. popup.stage_title Head Avdieienko Anatolii P., Доктор хімічних наук Registration Date 12-08-2024 Organization Donbass State Engineering Academy popup.description2  Object of research: N-carbamoyl-, N-arylaminocarbonyl-1,4-benzoquinone imines. Purpose: to develop a method for determining the redox potentials of N-carbamoyl-, N-arylaminocarbonyl-1,4-benzoquinone imines and their measurement. Methods: organic synthesis, physicochemical methods of research of organic compounds: elemental analysis, IR, 1H NMR, 13C NMR spectroscopy, direct potentiometry. Results: N-carbamoyl-, N-arylaminocarbonyl-1,4-benzoquinone imines have been synthesized. Their redox potentials were measured by direct potentiometry. It was established that their redox potentials were close to the redox potentials of redox pairs, which were measured by potentiometric titration of 4-arylsulfonylbenz(methyl)imidoyl-aminophenols with lead tetraacetate in a 0.5 M solution of sodium acetate in glacial ethanoic acid. It was experimentally shown the relationship between the nature of the substituent in the para-position of the aryl fragment of N-arylaminocarbonyl-1,4-benzoquinone imines and their redox potential: with increasing electron-accepting properties of the substituent the redox potential of quinone imine increases. Efficacy: The results provide important information for predicting the behavior of these quinone imines in different biological systems when using their reduced forms as drugs. This allows to purposefully search for new drugs based on similar structures, as well as search for the most rational ways of their synthesis based on information about their redox properties. Product Description popup.authors Avdieienko Anatolii P. Konovalova Svitlana А. Mienafova Yuliia V. Marchenko Inna L. Santalova Hanna A. Kholmovyi Yurii P. Yusina Hanna L. popup.nrat_date 2024-08-12 Close