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Registration Number

0224U032212, 0123U102561 , R & D reports

Title

Experimental and pharmacological approaches to the study of pathological conditions of the body

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Head

Veselovskyi Mykola S., Доктор біологічних наук

Registration Date

14-08-2024

Organization

Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine

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 It was established that NA causes a decrease in the frequency of impulses of GTN neurons by an average of 40% with a sufficiently wide range of inhibition. It was shown that in old animals, glutathione restores endothelium-dependent relaxation responses of isolated vascular preparations to acetylcholine administration, which were prevented by the NO-synthase inhibitor L-NAME, which may indicate an NO-dependent mechanism of relaxation of these vessels. Studies have shown that TRPV1 and TRPM8 in the smooth muscle cells of the urogenital tract are localized on the intracellular membrane of the sarcoplasmic reticulum, and are involved in cholinergic excitation and are responsible for temperature sensitivity. Testing CNPs' protective effects, we observed their low toxicity to neurons and a significant reduction in dead hippocampal neurons in the presence of Aβ, suggesting neuroprotective properties. This indicates the potential promise of CNPs in developing AD treatments.

Product Description

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Vasylenko Maryna I.
Veselovskyi Mykola S.
Hanzha Vita V.
Горковенко Andrii V.
Zavhorodnyi Mykola O.
Zavodovskyi Danylo O.
Kaleinikova Oksana M.
Kondratska Olena А.
Levashov Mykhailo I.
Lukianets Olena O.
Lunko Oleksii O.
Maslov Vitalii Yu.
Mys Lidiya A.
Rozova Kateryna V.
Rozumna Nataliia M.
Skibo Halyna H.
Sotkis Hanna V.
Strutynska Nataliia A.
Strutynskyi Ruslan B.
Ihor В. Philіppov
Tsupykov Oleh Mykhailovych
Shapovalova Anna S.
Yanko Roman V.

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2024-08-14