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Information × Registration Number 0224U032216, 0118U007345 , R & D reports Title NCS protein signaling in CNS neurons in norm and pathology. popup.stage_title Head Bilan Pavlo V., Доктор біологічних наук Registration Date 14-08-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2 We have shown that N75K mutant НРСА, contrary to the WT HPCA, cannot translocate to the plasma membrane of dendritic compartments in response to physiologically relevant patterns of neuronal activity. This impairment renders the mutant incapable of controlling slow afterhyperpolarization and, consequently, increases neuronal excitability likely underlying primary dystonia. Product Description popup.authors Bilan Pavlo V. Hryshchenko Oleksii V. Dovhan Oleksandr V. Dromaretskyi Andrii V. Kononenko Mykola I. Kulahina Iryna B. Sheremet Yevhenii Yu. popup.nrat_date 2024-08-14 Close