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Information × Registration Number 0224U032220, 0119U103909 , R & D reports Title Molecular and genetic mechanisms of hypoxia influence on inflammation and metabolic disorders popup.stage_title Head Portnychenko Alla H., Доктор медичних наук Registration Date 15-08-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  During the implementation of the project, mitochondrial, microRNA-dependent and molecular mechanisms of the development of inflammation and metabolic disorders, in particular, insulin resistance and type 2 diabetes mellitus, as well as their comorbid course, were established, and hypoxic therapeutic and pharmacological approaches to their correction in the experiment and clinic were developed. Manifestations of mitochondrial and endothelial dysfunction, oxidative stress, activity of antioxidant enzymes, expression of metabolic regulator proteins are characterized as pathogenetic links of the comorbid course of inflammation and metabolic disorders when they are modeled in the experiment. The participation of microRNA-34a and -320 and leptin in the implementation of the effects of hypoxic influences on metabolic disorders in experimental insulin resistance and type 2 diabetes was determined. For the first time, the role of mitochondrial leptin receptors in the regulation of energy metabolism and mitochondrial dysfunction in the comorbid course of inflammation and metabolic disorders was established. Methods of hypoxic correction have been developed and modes of their use in inflammatory processes and manifestations of the metabolic syndrome, in particular, insulin resistance and type 2 diabetes, have been determined. Product Description popup.authors Abuvatfa Cami A. Rufat B. Aliiev Bakunovskyi Oleksandr M. Vasylenko Maryna I. Vashchenko Nataliia M. Harmatina Olha Yu. Honchar Olha О. Dubova Mariia H. Zhukovska Anna S. Zavhorodnyi Mykola O. Klymenko Oksana O Kozlovska Mariia H. Mankovska Iryna M. Moiseenko Yevhen V. Nosar Valentyna I. Rozova Kateryna V. Tsapenko Petro K. Shapovalova Anna S. popup.nrat_date 2024-08-15 Close