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Information × Registration Number 0224U032227, 0118U007348 , R & D reports Title The role of long non-coding RNA in the development of experimental and clinical pathology popup.stage_title Head Dosenko Victor Ye., Доктор медичних наук Registration Date 15-08-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  The search for new molecular mechanisms of the development of the most common human diseases is a relevant and promising area of modern medical science. In this regard, long non-coding RNAs (lncRNAs), as a new class of regulatory molecules, are considered to be extremely important in understanding the etiology, pathogenesis, search for new therapies, diagnosis and control of many diseases, including cardiovascular diseases. According to our hypothesis, dysregulation of lncRNA expression is crucial for the dysregulation of the following fundamental processes in adaptation and pathology: hypoxia, autophagy, PPAR signaling, activation of ATP-sensitive potassium channels, and formation of neutrophil extracellular traps. Using different models of cardiovascular pathology and clinical material, we plan to study the role of lncRNAs in the above processes at the level of lncRNA, mRNA, protein, microRNA expression, enzyme activity, morphological and functional level, and ultrastructural level. Product Description popup.authors Dosenko Viktor Ye. Dubrovskyi Yevhen I. Lahuta Tetiana I. Nahibin Vasyl S. Pashevin Denys O. Serebrovska Zoia O. Stroi Dmytro O. Strutynskyi Ruslan B. Tumanovska Lesia V. Hetsuriani Mykhaylo R. Shysh Anzhela M. popup.nrat_date 2024-08-15 Close