Search academic texts

Information × Registration Number 0224U032577, (0121U110812) , R & D reports Title To study the condition of the respiratory system and developing rehabilitation measures for children with recurrent respiratory diseases who have suffered COVID-19 popup.stage_title Вивчити стан дихальної системи та розробити реабілітаційні заходи для дітей з рекурентними респіраторними захворюваннями, які перенесли хворобу COVID-19 Head Antypkin Yurii Н., Доктор медичних наук Registration Date 20-11-2024 Organization State institution «Ukrainian center of maternity and childhood of the National academy of medical sciences of Ukraine» popup.description1 To increase the efficiency of diagnosis and rehabilitation of children with recurrent diseases of the upper and lower respiratory tract during the pandemic COVID-19 by studying the functional state of external respiration, the state of the respiratory epithelium of the upper and lower respiratory tract, polymorphism ss469415590 gene IFNL4 and IFNL4 gene. popup.description2  As a result of research, it was established that among children who were sick with COVID-19, 47.2% of patients were children with recurrent respiratory diseases. In the structure of COVID-19 among this category of children, the severe course of the disease occurred significantly more often (in 22.3%). It was established that restrictions on social distancing (living in a dormitory, presence of ≥ 5 family members, visiting clubs), incomplete vaccination status of the child, age of the mother < 20 years and > 35 years, and a history of pneumonia before the age of 3 years were medically probable - social risk factors for the development of COVID-19. It was determined that the SS genotype of the rs12979860 polymorphism of the IFNL gene is associated with cases of RRZ among children and is a prognostic marker of the risk of developing pneumonia caused by the SARS-CoV-2 virus. Among children with RRZ, the odds of contracting COVID-19 were two times higher with insufficient vitamin D levels and four times higher with vitamin D deficiency. It was established that in 67.5% of children with RRZ, after suffering from COVID-19, post-COVID changes in the respiratory system were registered, which depended on the severity of COVID-19 and were characterized by: restrictive disorders of lung function (47.5%), the formation of bronchial hyperreactivity (10.0%), the preservation of inflammatory changes in the respiratory tract and the tendency to decrease expressing killer (CD56+) and macrophage (CD68+) cells. The algorithm for the differentiated appointment of therapeutic and preventive measures with the use of cholecalciferol, interferon prophylaxis and ectoine-based cytoprotector has been scientifically substantiated and developed. Product Description popup.authors Antypkin Yurii H. Buratynska Antonina A. Harashchenko Tetiana A. Zadorozhna Tamara D. Kaminska Tetiana M. Livshyts Liudmyla A. Lapshyn Volodymyr F. Pustovalova Olha I. Stepanova Liliia S. Stryzhak Svitlana K. Umanets Tetiana R. popup.nrat_date 2024-11-20 Close