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Registration Number

0224U032741, (0122U001154) , R & D reports

Title

Physical bases of formation of apatite-biopolymer-carbon 3D nanometric scaffolds for biomedical purpose with prolonged delivery of antimicrobials to the implantation area

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Експериментальний синтез та вивчення основ формування композитів з вмістом вуглецевих наночастинок (фулерену С60). Експериментальний синтез апатит-біополімерних композитів медичного призначення з вмістом MWСNTs+Fe та cdHA

Head

Sukhodub Leonid F., д.ф.-м.н.

Registration Date

03-12-2024

Organization

Sumy State University

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Establishing the physical basis for the formation of 3D nanometric matrices based on calcium deficiency hydroxyapatite (cdHA), as well as natural polysaccharides of chitosan (CS), alginate (Alg), carbon nanoparticles, bioactive substances, mesenchymal stem cells and laying the foundation for creating biomaterials with specified functional characteristics both the consequences of socially significant human diseases (military, industrial and domestic injuries) and the improvement of quality of life through the introduction of comprehensive therapies

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 The following new scientific results were obtained during the implementation of the NDR: 1. The basic technology for the synthesis of composite materials based on natural polymers (alginate (Alg), gelatin (Gel), chitosan (Cs)), modified with metal nanoparticles (NPs) and polyaniline (PANI) was developed; it was proved that 0.15 mg/ml Ag, Cu, and ZnO NPs increase the composites’ electrical conductivity (EС) by 4, 1.6, and 4.3 times, and PANI content of 0.05, 0.1, 0.5 mg/ml - by 19, 25, and 42 times, respectively; the composites do not cause cytotoxicity against L929 cells. 2. Alg-Gel-based nerve conduits, modified with ZnO and C60 fullerene NPs, demonstrate sufficient (up to 630%) water absorption capacity and mechanical stability in vitro; structure modification with ZnO and C60 NPs increases the swelling degree by 3.6 and 21%, respectively, the porosity by two times, and hydrophilicity by 15%. 3. Determined factors influencing the mechanical properties of composites: for Alg/Gel/PANI, ZnO/Alg/Gel/PANI, C60/Alg/Gel/PANI samples in the form of disks, Young's modulus is 2.7, 5.1, 4.9 MPa, and in the form of tubes - 13.7, 10.7, 12 MPa, respectively. NPs increase the elasticity and reduce the relative deformation of composites. 4. For the first time, the antioxidant activities (AOA) of Quercetin (Qu) and Rosemary Extract (RE) immobilized in osteoplastic hydroxyapatite (HA) - biopolymer materials doped with ZnO micro- and nanoparticles and Zn2+ ions were investigated in detail. Qu-HA-Alg-ZnONPs samples with Qu loaded both during synthesis and saturation showed the highest AOA after 54 h (76.93 and 93.97%, respectively). The AOA of RE-HA-Alg-Zn2+(S) and RE-HA-Alg-ZnONPs(S) samples was 75.33 and 88.52%, respectively. 5. The osteoplastic biomaterial's in vivo biocompatibility and regenerative potential with zinc ions content has been proven.

Product Description

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Bozhko Nataliia V.
Korenkov Oleksii V.
Kumeda Mariia O.
Sukhodub Leonid F.
Sukhodub Liudmyla B.

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2024-12-03