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Registration Number

0224U032758, (0123U102850) , R & D reports

Title

Research And Development Of Ion-Plasma Technologies for Synthesis of Complex Composite Multifunctional Coatings For Medical Implants And Biosafety

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Дослідження та розробка технологій іонно-плазмового синтезу антибактеріальних покриттів, дослідження біологічно значущих параметрів синтезованих покриттів на експериментальних зразках, медичних імплантатах та виробах широкого використання

Head

Lisovskyi Valerii O., Доктор фізико-математичних наук

Registration Date

03-12-2024

Organization

V.N. Karazin Kharkiv National University

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Research and development of technologies of ion-plasma synthesis of multifunctional (protective, bioinert, antibacterial) multilayer coatings based on oxides and nitrides of transition metals on the surface of metal and polymeric medical implants, research of physico-mechanical and electrochemical properties of the coatings, and justification of the coatings application by in vivo studies of the body's biological response to the coated implant.

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 Technologies for reactive ion-plasma synthesis of combined antibacterial coatings based on oxides and nitrides of a mixture of a biologically passive metal with a metal that has a bactericidal effect have been developed. An experimental sample of a device for the synthesis of coatings based on silver in combination with tantalum oxide has been manufactured, which made it possible to apply combined coatings with any ratio of concentrations of the base metal (tantalum or aluminum) and bactericidal metal (silver or copper). Simultaneous introduction of a plasma-activated reactive gas (oxygen or nitrogen) allowed the deposition of oxide or nitride coatings. Thus, a large number of different combined coatings were synthesized (Ag, AgO, Ta-Ag-O, Ta-Ag-N, Al-Cu-O, Al-Cu-N). A large number of samples with antibacterial coatings of different compositions were obtained, each of which was tested for bactericidal activity. Microbiological testing was carried out using two cultures: Escherichia coli and Staphylococcus aureus. The results of the studies showed that the most effective are coatings based on silver oxide, which act much more effectively than silver. Tests with different coating thicknesses in the range of 20 nm - 2 μm showed that there is no dependence on the thickness of the coating, bactericidal activity is provided only by a thin surface layer of the coating. The most promising material for hard antibacterial coatings was recognized as silver oxide.

Product Description

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Yefimenko Nina O.
Azarienkov Mykola O.
Dudin Stanislav V.
Zykov Oleksandr V.
Mazilin Bohdan O.
Yakovin Stanislav D.

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2024-12-03