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Information × Registration Number 0224U032792, (0123U103867) , R & D reports Title Development of a novel, nanoparticle-based disinfectant for deactivation of pathogens causing emergent infectious diseases popup.stage_title Проміжний Head Bielikov Kostiantyn M., Кандидат хімічних наук Registration Date 05-12-2024 Organization State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine popup.description1 Studying metal and metal oxide nanoparticle action on biological models with different levels of organization (viruses, bacteria, fungi, endoparasites, animals) in order to develop a novel, wide-range, sustained-release disinfectant based on nanoparticles popup.description2  The project will include the synthesis of Ag, Cu, Fe, Zn-Ag, Fe-Ag, Cu-Ag nanoparticles stabilized by surfactants with a pronounced antiseptic effect, as well as the synthesis of ZnO, CuO and iron oxides nanoparticles with further development of methods for their doping with metals. The biocidal activity of metal nanoparticles will be investigated, including the study of virucidal activity against the causative agent of bovine coronavirus infection, avian influenza H5N2, the study of bactericidal action against Salmonella, enterobacteria, mycobacteria, fungicidal (fungistatic) action of nanoparticles and the study of disinvasive action on helminth eggs. Based on the research, the optimal formulation of an innovative disinfectant will be developed and the modes of its application for preventive and forced disinfection of livestock facilities will be determined. The project will include determination of the toxicological characteristics of the developed product in laboratory animals, preclinical and clinical trials of the developed product (on the basis of various agricultural enterprises), study of the migration of nanoparticles into the body of target animals and study of their environmental impact. These tasks will be accomplished with the extensive use of modern methods of nanoparticle synthesis, as well as with the use of modern virological, bacteriological, toxicological and biochemical methods. The effectiveness of the developed disinfectant will be studied under the conditions of treatment of the territory of livestock premises both without and in the presence of animals. The effect of the developed disinfectant on the organism of the target animals will be established by studying hematological and biochemical blood parameters in accordance with standard methods. The created innovative disinfectant based on metal nanoparticles will have a wide range of antimicrobial effects, will be effective against pathogens of emergent infectious diseases. Product Description popup.authors Bielikov Kostiantyn M. Brylova Kateryna Yu. Bunina Zinaida Yu. Varchenko Viktoriia V. Zavhorodnii Andrii I. Kovalenko Liudmyla V. Korneikov Oleksandr M. Palii Anatolii P. Sumakova Nataliia V. Sheina Tetiana V. Shcherbakov Ilias B. popup.nrat_date 2024-12-05 Close