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Information × Registration Number 0224U032798, (0119U100887) , R & D reports Title Modern views on the morphogenesis of general pathological processes. popup.stage_title Сучасні погляди на морфогенез загальнопатологічних процесів Head Romaniuk Anatolii M., Доктор медичних наук Registration Date 05-12-2024 Organization Sumy State University popup.description1 to identify the modern features of the morphogenesis of general-pathological processes by using histological, histochemical and molecular-genetic methods of diagnostics. popup.description2  Object of Study: The research focuses on the pathomorphological characteristics of general pathological processes and the variability of pathological conditions in relation to the qualitative and quantitative composition of tissues. Aim of the Study: The objective is to identify the specific features of variability in the morphological and immunohistochemical composition of tissues during the development and progression of pathological processes. Research Methods: The study employed macroscopic and microscopic examinations, immunohistochemical and immunofluorescent analyses, as well as molecular-genetic and statistical methods. Key Findings: the uterus of sexually mature rats exhibited a typical structure with distinct morphological characteristics, which were altered under the influence of heavy metal salts. This exposure resulted in a decreased expression of estrogen and progesterone receptors; skin irradiation led to an increase in the density of melanosomes without altering the number of melanocytes; in the investigation of ovarian cancer and meningiomas with pathological biomineralization, there was an increased expression of osteoblastic markers, indicating active calcification associated with tissue dystrophy. The primary biomineral identified was calcium hydroxyapatite; analysis of hyperplastic processes in the endometrium revealed variability in the expression of ERα and COX-2, which may contribute to the development of related pathologies. Conclusions: The findings underscore the need for a comprehensive approach in the diagnosis and treatment of pathologies related to hormonal imbalances, toxic exposures, and biomineralization. The results of this research have been integrated into the educational curriculum of the Department of Pathological Anatomy Product Description popup.authors Budko Hanna Yu. Hyriavenko Nataliia I. Denysenko Anastasiia P. Karpenko Liudmyla I. Kuzenko Yevhen V. Lyndin Mykola S. Lyndina Yuliia M. Moskalenko Roman A. Romaniuk Anatolii M. Sikora Vladyslav V. Sikora Kateryna O. Sulym Anatolii H. Tsyndrenko Nataliia L. Chyzhma Ruslana A. popup.nrat_date 2024-12-05 Close