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Registration Number

0224U032830, (0124U004368) , R & D reports

Title

Regulatory systems in essential metabolism of Streptomyces albidoflavus J1074: discovery and biotechnological application

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Ідентифікація, клонування та функціо-нальна валідація генів транскрипційних регуляторів

Head

Ostash Bohdan O., Доктор біологічних наук

Registration Date

06-12-2024

Organization

Ivan Franko National University of Lviv

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To uncover novel regulatory systems embedded in primary metabolism of Streptomyces albidoflavus J1074 and apply them to assist and inform metabolic engineering

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 An idea of this work is to develop such expression systems on the basis of primary metabolic genes of the well-studied streptomycete S. albidoflavus J1074. During the 2024 target genes have been picked up that are believed to be promising for development of expression systems. Strains of J1074 have been generated carrying the DNA constructs where regulatory gene controls the expression of genes for fluorescent proteins, whose expression level can be facilely detected and quantified. This paves the way for a detailed study of the behavior of the genes under study, with a final aim to reveal those with the highest potential to become well-controlled tools for strong gene expression in actinomycetes.

Product Description

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Bilyk Bohdan R.
Bahriichuk Kateryna V.

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2024-12-06