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Information × Registration Number 0224U032860, (0124U004065) , R & D reports Title Redox-active complexes based on oxide nanoparticles and organic biologically active molecules for non-toxic chemotherapy. popup.stage_title Отримання оксидних наночастинок з контрольованою редоксактивністю та дослідження механізмів формування цієї активності. Head Seminko Vladyslav V., Доктор фізико-математичних наук Registration Date 09-12-2024 Organization Institute for Scintillation Materials of National Academy of Science of Ukraine popup.description1 The goal of the project is to create the redox-active supramolecular complexes based on organic molecules and oxide nanocrystals with ions of variable valence that are suitable for selective destruction of cancer cells; to determine the mechanisms of the pro-oxidant action of the obtained SMC in dependence of the chemical composition, size, shape and nanocrystal defective structure as well as from the nature of the interaction of nanoparticles and organic compounds in the SMC composition and the role of individual components in the formation of their redox properties. popup.description2 During implementation of the first stage of the project, nanoparticles with ions of variable valence (cerium oxide and orthovanadates of rare earth elements) were obtained and complexes of these nanoparticles with vitamins C and K were developed. These nanoparticles were characterized and the processes of their interaction with reactive oxygen species and biological molecules in aqueous solutions were investigated. It was shown that the obtained nanoparticles and complexes are capable of effectively oxidizing molecules of glutathione, L-cysteine, and dithiothreitol at neutral and weakly acidic pH values, and for the complexes, a synergistic effect of inorganic and organic components of the synthesized complexes is observed. These results indicate that the complexes obtained in the work can directly affect the redox balance in cancer cells. At the next stages, the effects of the prooxidant action of nanoparticles and complexes based on them, which were obtained in aqueous solutions, will be tested on cancer cells, which will make it possible to determine the possibility of using the obtained materials as drugs for anticancer therapy. Product Description popup.authors Dudetska Halyna V. Kavok Natalia S. Kot Yurii H. Maksymchuk Pavlo О. Seminko Vladyslav V. popup.nrat_date 2024-12-09 Close