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Information × Registration Number 0224U032895, (0124U004748) , R & D reports Title Development of new materials based on supramolecular systems for biomedical and veterinary applications popup.stage_title Етап предорганізації Head Chebanov Valentyn A., Доктор хімічних наук Registration Date 10-12-2024 Organization State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine popup.description1 Development of new materials for biomedical and veterinary use based on supramolecular systems of the host-guest, rotaxane and pseudorotaxane types, as well as other topologies using cucurbiturils, cyclodextrins and their modified analogues as receptors. popup.description2  The project aims to address the needs of the diagnostic technology market and resolve current challenges in veterinary medicine related to low bioavailability and rapid release of active substances. The primary goal of the project is to develop new biomedical and veterinary materials based on supramolecular systems of the "host-guest" type, rotaxane and pseudorotaxane types, and other topologies using cucurbiturils, cyclodextrins, and their modified analogs as receptors. During the first phase of the project, supramolecular systems based on triazole-containing carboxylic acid derivatives and cucurbiturils with ring sizes of 6 and 7 were synthesized. The formation of complexes was confirmed using thermogravimetric analysis, differential scanning calorimetry, and scanning electron microscopy. The structural features and binding energies of the supramolecular systems were studied using quantum-chemical methods and molecular dynamics. It was demonstrated that, for three cucurbiturils (sizes 6, 7, and 8), the most stable structure involved heterocyclic acids entering the host cavity via their thioacetic fragment. Based on the study of the spectral and photophysical properties of various fluorescent compounds, it was established that the most promising dyes for creating rotaxane systems include acridine orange and its dimers, polymethine, styryl, and triphenylpyrazoline dyes. Squaraine rotaxanes containing both unsubstituted and fluorinated fragments in the macrocycle were synthesized. Encapsulation of the squaraine dye within the macrocycle enhances its photostability and quantum yields. The project involves establishing a new infrastructure unit with the creation of a center for the collective use of scientific instruments, contributing to the further development of supramolecular chemistry in Ukraine. During the reporting period, a freeze dryer (lyophilizer) was procured and installed. Product Description popup.authors Zbruiev Oleksandr I. Kolosova Olha S. Kulyk Olesia H. Miasnikova Dariia Yu. Pinchukova Nataliia O. Sakhno Yana Igorivna Svoiakov Rostyslav Р. Chebanov Valentyn A. popup.nrat_date 2024-12-10 Close