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Information × Registration Number 0224U032995, (0124U003514) , R & D reports Title Multiparticulate mechanoactivated nanoarsenicals as advanced biomarkers with guided optical-fluorescence functionality popup.stage_title Вивчення явищ фізичного старіння в зразках As4S4-збагачених нанокомпозитів типу (As4S4)x(Fe3O4)1-x різного хімічного складу, квантово-хімічне моделювання їх структури, функціональна характеризаціяч оптико-флюоресцентними, магнітними та мікроструктурними методами. Head Boyko Vitalii T., Кандидат фізико-математичних наук Registration Date 13-12-2024 Organization Ivan Franko National University of Lviv popup.description1 - to develop multiparticulate (As4S4/Fe3O4) nanocomposites, based on anticancer drug such as As4S4 arsenical combined with magnetic-delivery component such as magnetite Fe3O4, where the former additionally possess optimized fluorescence (optical marker) properties, employing mechanochemical activation in high-energy ball mill operated in dry and wet modes, and - to optimize their functionality due to complementary microstructure research, including ab-initio quantum-chemical modeling (the cation-interlinked network clusters approach, CINCA), X-ray diffraction (XRD) in relation to diffuse halos and Raman scattering spectroscopy (RSS). popup.description2 This research deals with high-energy mechanochemical activation to fabricate (As4S4)x(Fe3O4)1-x nanocomposites (0<x<0.6) based on known anti-cancer drug (As4S4 arsenical) in combination with magnetic component (Fe3O4), the former possessing additional optical marker properties due to fluorescence in nm-confined medium. The molecular-network tendencies in evolution of arsenicals are recognized employing quantum-chemical modeling. The 3D-visualization fluorescence counter plots of the nanocomposites are drawn, and respective spectral dependences of fluorescence excitation-emission are reconstructed. At the basis of the results, the As4S4/Fe3O4 nanocomposites prepared in (Polaxamer 407) environment are defined as effective fluorescent-magnetic-therapeutic agents for advanced biomedical usage with guided function of optical biosensor. Product Description popup.authors Volodymyr T. Adamiv Boiko Vitalii T. Mys Oksana H. Shpotiuk Liubov Yo. Shpotiuk Oleh Yo. popup.nrat_date 2024-12-13 Close