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Information × Registration Number 0224U033148, (0121U111586) , R & D reports Title Study the role of genetic facrors in development of nervous system pathology and functioning of the stem cells in experiment popup.stage_title Визначення ролі генетичних факторів у розвитку патології нервової системи та функціонуванні стовбурових клітин в експерименті Head Labunets Iryna F., Registration Date 19-12-2024 Organization State Institution "National Scientific Center "Institute of Cardiology, clinical and regenerative medicine named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine popup.description1 To determine the influence of the haplotype of mice on the H-2 system on some mechanisms of development of neurodegenerative pathologies in the experiment, as well as on the biological properties of multipotent mesenchymal stromal cells (MMSC) in normal and transplantation into the body with pathology popup.description2 In adult mice FVB/N (haplotype H-2q) and 129/Sv (haplotype H-2b) strains with a toxic model of parkinsonism the changes in the number of neuroinflammatory cells (T-lymphocytes, macrophages), the activity of antioxidant enzymes in the brain, the structure of central nervous system neurons of the nervous system and behavioral reactions are depended on their haplotype. The influence of the H-2 haplotype on the biological properties of multipotent mesenchymal stromal cells (MMSC) in the bone marrow of intact mice, animals with a model of parkinsonism and under the conditions its exposure in vitro to melatonin was shown. The positive effect of human umbilical MMSC on behavior, the structure of hippocampal neurons, indicators of neuroinflammation and oxidative stress in parkinsonism depends on the H-2 haplotype of mice. The results can be useful in studying the influence of genetic factors on the pathogenesis of parkinsonism and justifying individualized approaches to cell therapy of this pathology.  Product Description popup.authors Dovbynchuk Taisa V. Kashchuk Olha A. Litoshenko Zoia L. Lehkostup Liudmyla A. Mykhalskyi Serhii A. Olar Petro O. Panteleimonova Tetiana M. Kharkevych Yurii O. popup.nrat_date 2024-12-19 Close