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Information × Registration Number 0224U033269, (0124U004387) , R & D reports Title Novel copper-loaded wound healing patches with advanced regeneration capacity and antibacterial effect popup.stage_title Проведення експерименту in vivo з оцінкою мікробіологічного профілю та патогістологічних змін рани. Розробка технології виробництва нових ранозагоювальних матеріалів Head Moskalenko Roman A., Доктор медичних наук Registration Date 23-12-2024 Organization Sumy State University popup.description1 development of novel electrospun wound healing patches, loaded with copper nanoparticles with controlled delivery popup.description2 Object of research – wound healing process The subject of research – dressing materials synthesized by electrospinning method based on polylactic acid (PLA) and chitosan (Ch) containing copper nanoparticles (CuNPs). To achieve the set goal, the following tasks were defined during the implementation of the stage: 1. Development of nanofibrous electrospun dressing materials based on polylactic acid and chitosan and immobilization of copper nanoparticles. 2. Evaluation of antibacterial properties of the developed dressing materials. 3. Application of the developed dressing materials on laboratory animals in vivo for the treatment of simulated wound infection. 4. Determination of the effectiveness of the use of dressing materials for wound treatment. 5. Evaluation of the toxic effect of copper nanoparticles on the internal organs of laboratory animals. Acute and chronic wounds are widespread medical problems that have a significant impact on the healthcare system. This problem has become particularly acute in Ukraine since the start of the full-scale Russian invasion. The increase in the number of injuries and damages contributes to the rapid spread of antibiotic-resistant strains of bacteria, which are very difficult to treat. In this regard, nanomaterials, in particular metal nanoparticles, attract special attention due to their unique antibacterial properties that do not cause resistance in microorganisms. Our project is aimed at developing modern copper-containing dressings for wound healing of various etiologies with controlled delivery. The development of new dressings using the electrospinning method, with the addition of chitosan and copper nanoparticles, is a highly effective solution to combat antibiotic resistance and chronicity of the process Product Description popup.authors Baryshok Alina S. Butsyk Anna S. Kruhliak Halyna M. Moskalenko Roman A. popup.nrat_date 2024-12-23 Close