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Information × Registration Number 0224U033287, (0123U102767) , R & D reports Title Hippocalcin-dependent regulation of long-term depression at normal conditions and primary dystonia popup.stage_title Дослідження відновлення функціональної довготривалої депресії при експресії нормального гіпокальцину у культурах нейронів, у яких буде проведено нокаут або нокдаун гену гіпокальцину Head Bilan Pavlo V., Доктор біологічних наук Registration Date 24-12-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 The main goal of this project is to investigate of molecular mechanisms of hippocalcin-dependent regulation of long-term depression and their changes evoked by DYT2 hippocalcin mutation popup.description2  Mutations in the hippocalcin gene have been associated with a neurological disease called primary isolated dystonia. This disease is characterized by symptoms such as spontaneous muscle contractions, tremors, and spasms. It's strongly linked to disorders in the mechanisms that regulate the plasticity of neuronal networks. Our research aimed to compare the normal form of hippocalcin with the disease-associated N75K mutant in a model of long-term synaptic depression, a crucial form of long-term neuronal plasticity. Our preliminary results suggest that the N75K mutation significantly disrupts the ability of hippocalcin to insert into membranes. We found that both the area of insertions along neuronal dendrites and the amount of hippocalcin at the insertion sites were significantly reduced in the disease- associated mutant Product Description popup.authors Bilan Pavlo V. Dovhan Oleksandr V. Kaspirzhnyi Anton V. Kononenko Mykola I. Olifirov Borys O. Sheremet Yevhenii Yu. popup.nrat_date 2024-12-24 Close