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Total number
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Number of local repositories
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0224U033360,
(0121U111584)
,
Modification of mesenchymal stem cells to increase their therapeutic activity
Модифікація мезенхімальних стовбурових клітин для підвищення їх терапевтичної активності
Kordium Vitalii A., Доктор біологічних наук
25-12-2024
State Institution "National Scientific Center "Institute of Cardiology, clinical and regenerative medicine named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine
Complex modification of MSCs in order to obtain on their basis highly effective prototypes of drugs
The method of comprehensive assessment of the influence of a number of factors on the immunomodulatory properties of human umbilical cord MSCs in vitro in the model of mitogen-induced proliferation in co-cultivation with human peripheral blood mononuclear cells was optimized. The influence of complexly modified human umbilical cord MSCs on experimental non-infectious diseases in laboratory animals was studied. It was shown that two-stage modification of MSCs led to a faster and more complete, compared to native MSCs, restoration of biochemical, morphological and behavioral indicators in non-infectious peritonitis in mice, acute pancreatitis in rats and toxic memory impairment in mice. In an in vitro model of influenza infection, it was found that complexly modified MSCs in high concentrations slightly reduce the level of influenza virus reproduction, and in vivo experiments showed 100% survival of experimental animals on the 6th day of the experiment in all variants of MSC preparation, compared to untreated control.
Horbatiuk Oksana B.
Deriabina Olena H.
Kovalchuk Mariia V.
Minchenko Zhanna М.
Morhunov Pavlo V.
Rymar Svitlana Yu.
Ruban Tetiana A.
Toporova Olena K.
Usenko Mariia O.
Shuvalova Nadiia S.
2024-12-25
Updated: 2025-12-07
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