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Information × Registration Number 0224U033422, (0124U000196) , R & D reports Title Development of new pharmacological therapies for correction of post-traumatic stress impairment. popup.stage_title Розробка та експериментальні випробування нових фармакотерапевтичних підходів з використанням N-стероїлетаноламіну та “Альфакогнітину” для корекції та усунення наслідків посттравматичного стресового розладу (ПТСР). Head Komisarenko Serhii V., Доктор біологічних наук Registration Date 27-12-2024 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 Development and experimental testing of novel pharmacological therapies using endogenous cannabimimetic N-stearoylethanolamine and a complex preparation “Alphacognitine” for correction and eradication of consequences of post-traumatic stress impairment (PTSI). popup.description2 The main links of the pathogenesis of posttraumatic stress disorder (PTSD) in mice were reproduced and validated in the forced swim immersion (FSI) model. The study of behavioral reactions of PSI-stressed mice showed that on the 7th day after the PSI procedure, the mice demonstrated behavioral signs of stress: increased anxiety, impaired episodic memory, impaired exploratory and locomotor activity, which characterized the acute phase of stress, which in the period from 7 to 12 days after PSI turned into PTSD. Treatment with NSE, "Alphacognitin" or their combination, started on the 7th post-stress day, contributed to the effective restoration of locomotor activity, emotional and cognitive functions. At the same time, the combined effect of the drugs was less effective compared to the individual effect of each of the drugs. It was found that on the 12th day after the VPS, high levels of adrenaline and noradrenaline and low levels of dopamine were preserved in the plasma of stressed mice, which indicates the presence of PTSD in animals. The studied drugs reduced the level of neuroinflammation, normalizing the content of stress-induced hormones (catecholamines and corticosterone), pro-and anti-inflammatory cytokines in the blood and brain of mice with PTSD. It was found that the neuroprotective properties of the drugs were realized through their enhancement of IL-6 production and expression of the α7 subunit of nAChRs. NSE and "Alphacognitin" therapy contributed to the restoration of the level of the astroglial marker GFAP in the hippocampus of mice with PTSD, which indicates the protection of astroglia from stress-induced atrophy. The administration of NSE prevented the increase in the level of circulating NF-L, which indicates the neuroprotective effect of the drug and the restoration of BBB integrity under its influence. Thus, NSE and "Alphacognitin" can be recommended for use in the pharmacotherapy of post-traumatic stress disorder and associated cognitive disorders Product Description popup.authors Bilous Vasil L. Goridko Tetyana M. Kalashnyk Olena M. Kolybo Denys V. Kosiakova Halyna V. Lykhmus Olena Yu. Meged Olena Fedorivna Siromolot Andrii A. Tykhomyrov Artem O. popup.nrat_date 2024-12-27 Close